Duce

FACULTY OF SCIENCE


Personal Information

Name:

Dr. Siana Watoky Nkya

Contact Address:

P.O Box 2329
TANZANIA.
Email: siana.nkya@duce.ac.tz, snkyamtatiro@gmail.com
(mobile) +255784193349

Education

  • Muhimbili University of Health and Allied Sciences, Tanzania/King’s College of London, UK: 2011-2016, Human Genetics
  • University of Dar es Salaam, Tanzania: 2004-2007: MSc Molecular Biology
  • University of Dar es Salaam, Tanzania: 2001-2004: BSc General (Microbiology and Chemistry
  • Research interests

    Human Genetics and Genomics

    Teaching areas

    • Advanced Genetics
    • molecular biology
    • Cell Biology and Genetics
    • Evolution

    Publications

    1. Nkya S, Mwita L, Mgaya J, Kumburu H, Van Zwetselaar M, Menzel S, Mazandu GK, Sangeda RZ, Chimusa ER, Makani J. Next generation sequencing unveils genetic variants and pathways associated with extreme HbF levels in individuals with SCD in Tanzania. 2019 Frontiers in Genetics.
    2. Nkya S, Mtei L, Soka D, Mdai V, Mwakale P, Mrosso P, Mchoropa I, Rwezaula S, Azayo M, Ulenga N, Ngido M, Cox SE, D'Mello BS, Masanja H, Kabadi G, Mbuya F, Mbando B, Streetly A, Killewo J, Tluway F, Limo M, Makani J. Newborn Screening for Sickle Cell Disease: An innovative pilot program to improve child survival in Dar-es-Salaam, Tanzania. 2019 International health.
    3. Ben Hamda C, Sangeda R, Mwita L, Meintjes A, Nkya S, Panji S, Mulder N, Guizani-Tabbane L, Benkahla A, Makani J, Ghedira K. common molecular signature of patients with sickle cell disease revealed by microarray meta-analysis and a genome-wide association study. PLoS One. 2018;13(7):e0199461. PubMed PMID: 29979707; PubMed Central PMCID: PMC6034806.
    4. Gardner K, Fulford T, Silver N, Rooks H, Angelis N, Allman M, Nkya S, Makani J, Howard J, Kesse-Adu R, Rees DC, Stuart-Smith S, Yeghen T, Awogbade M, Sangeda RZ, Mgaya J, Patel H, Newhouse S, Menzel S, Thein SL. g(HbF): a genetic model of fetal hemoglobin in sickle cell disease. Blood Adv. 2018 Feb 13;2(3):235-239. PubMed PMID: 29437638; PubMed Central PMCID: PMC5812320.
    5. Menzel S, Rooks H, Zelenika D, Mtatiro SN, Gnanakulasekaran A, Drasar E, Cox S, Liu L, Masood M, Silver N, Garner C, Vasavda N, Howard J, Makani J, Adekile A, Pace B, Spector T, Farrall M, Lathrop M, Thein SL. Global genetic architecture of an erythroid quantitative trait locus, HMIP-2. Ann Hum Genet. 2014 Nov;78(6):434-51. PubMed PMID: 25069958; PubMed Central PMCID: PMC4303951.
    6. Mtatiro SN, Mgaya J, Singh T, Mariki H, Rooks H, Soka D, Mmbando B, Thein SL, Barrett JC, Makani J, Cox SE, Menzel S. Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer. BMC Med Genet. 2015 Feb 10;16:4. PubMed PMID: 25928412; PubMed Central PMCID: PMC4422446
    7. Mtatiro SN, Makani J, Mmbando B, Thein SL, Menzel S, Cox SE. Genetic variants at HbF-modifier loci moderate anemia and leukocytosis in sickle cell disease in Tanzania. Am J Hematol. 2015 Jan;90(1):E1-4. PubMed PMID: 25263325; PubMed Central PMCID: PMC4737118
    8. Mtatiro SN, Singh T, Rooks H, Mgaya J, Mariki H, Soka D, Mmbando B, Msaki E, Kolder I, Thein SL, Menzel S, Cox SE, Makani J, Barrett JC. Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania. PLoS One. 2014;9(11):e111464. PubMed PMID: 25372704; PubMed Central PMCID: PMC4221031